Frazier's statement - along with those of scores of others, including many Republicans - may have even had an impact on Trump's decision, later Monday, to get more specific about what happened in Charlottesville.
Frazier, one of only a few black CEOs to helm a Fortune 500 company, said in a statement that Trump "must honor our fundamental views by clearly rejecting expressions of hatred, bigotry and group supremacy".
The CEO of the nation's third largest pharmaceutical company is resigning from the President's American Manufacturing Council citing "a responsibility to take a stand against intolerance and extremism".
Plank sparked boycott threats from the opposite side of the political spectrum this year after he called Trump "a real asset for the country" in an interview that turned the company into a political lightning rod.
But he plans to stay on a separate Trump advisory panel and said the president's follow-up remarks on Monday that named white supremacists were a step in the right direction.
In the aftermath of those comments, Poser downgraded Under Armour and said Plank's praise for Trump made it "nearly impossible to effectively build a cool urban lifestyle brand in the foreseeable future".
One other member, Dell, said there was "no change" in how it is "engaging with the Trump administration" on policy issues that affect the company.
Privately, many chief executives say they are fuming, outraged by the president. Continuing the trend on Tuesday, Scott Paul, CEO of the Alliance for American Manufacturing also tweeted his resignation.
Business Leaders Quit Trump Panel; He Hits Back Hard
But they also said they'd stay on the council so they could advise the government on ways to strengthen manufacturing. Privately, many chief executives say they are fuming, outraged by the president.
The White House tried to stem the damage on Sunday.
Richard Trumka, president of the largest federation of USA labor unions, the AFL-CIO, questioned the council's effectiveness and said the group was mulling leaving.
The head of one of the largest unions in the USA announced Tuesday that he was stepping down from President Donald Trump's business advisory board.
Many corporate leaders have faced a lose-lose scenario in which any choice involving politics can alienate customers, not to mention a USA president who has shown a willingness to personally negotiate government contracts.
Richard Trumka, leader of the AFL-CIO, issued a statement on Tuesday saying "I can not sit on a council for a President that tolerates bigotry and domestic terrorism".
Two days later and after intense criticism, Trump on Monday called out the KKK, neo-Nazis and white supremacists as "evil" and "hate groups" that are "repugnant to everything we hold dear as Americans".
SpaceX founder Elon Musk and Disney CEO Robert Iger bowed out of their respective positions when Trump said he would pull the US out of the Paris climate agreement.
The president denied that his original statement about the violence in Virginia on Saturday - saying "many" sides were to blame, rather than hate groups - was the cause of the departures. Musk also left the manufacturing council.