The action sequel, which arrived in theaters on Wednesday, took in over $69 million between opening night and Sunday, $45.3 of which was on its opening 3-day weekend, according to film tracking website Box Office Mojo.
Second place was a virtual tie between the animated adventure, Cars 3, last weekend's leader, and Wonder Woman each with $25-million. Worldwide, the Gal Gadot-starring Wonder Woman has grossed a total of $652.9 million for studio Warner Bros.
The top total grossing movie on this weeks global top 10 is Pirates of the Caribbean: Salazars Revenge which is still released in 56 countries and has a global gross of $677.8 million.
Paramount executives and other investors aren't likely wringing their hands this week after Transformers: The Last Knight debuted in China with $120 million*, but beneath those box office numbers lie some troubling signs suggesting Chinese moviegoers - who have contributed an increasingly larger share to the franchise's global box office over the past decade - are losing interest in Michael Bay's bombastic vision.
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Image: Actress Laura Haddock arrives for the U.S. premiere of the film "Transformers: The Last Knight" in Chicago, Illinois, U.S., June 20, 2017.
I'm proud of you, domestic audiences! "I mean, that's just the Michael that I know, but you never know, sometimes people decide to move on, so we'll see what happens". It's been nearly a month since Wonder Woman first hit theaters, 24 days at the box office with $318.1 million and counting.
Likewise, Guy Ritchie's "Arthur: Legend of the Sword" made $137 million at the box office, just enough to consider it an abject failure.
Future business will tell whether those grosses are enough to cover a hugely expensive movie: $217 million to make, plus almost as much to market. "Transformers 5" made $123 million in China in its first week. The previous movie in the series, "Age of Extinction", made the majority of its money ($858.6 million) overseas.
And Kumail Nanjiani's critically adored romantic comedy "The Big Sick" should earn $435,000 during its opening weekend in five locations - that would give the Lionsgate and Amazon Studios release the highest per screen average of any film that has opened this year so far.