A Kent Police statement said: "At around 2.50pm on Thursday, June 15, a collision involving a white lorry, white van and blue Honda motorbike occurred on the Essex-bound carriageway of the A282 just before the Dartford crossing".
The M25 anti-clockwise in Kent is now closed between J2 and J1b of the A282, while we assist police and emergency services with a serious collision.
There are also long delays back into Essex on the southbound carriageway, as police attempt to deal with the incident.
Police officers and South East Coast Ambulance Service are at the scene where the carriageway has been closed at junction 2 and a diversion is being put in place to allow traffic to re-join the A282 at junction 1B.
Kent Police's roads department is urging motorists to avoid the area and use alternative routes.
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A motorcyclist has died after a crash near the Dartford crossing yesterday.
The condition of other drivers involved is not known at this time. Emergency services have been contacted for updates.
"Drivers are advised to seek alternative routes".
Hours of delays are expected on the Dartford Crossing this evening after two multi-vehicle pile-ups brought traffic to a standstill.