SBW is battling a knee injury which saw him sit out Friday's win over the Reds but he ran freely at training on Monday.
Although he trained with the side on Monday, he was bracketed at inside centre with TJ Faiane when the side was named to play the Lions.
Perofeta, the Taranaki playmaker, made his Super Rugby debut against the Reds in Apia last weekend, coming off the bench in the second half.
Roaring return: Sonny Bill Williams looks likely to return from injury for the Blues, as they face the British and Irish lions.
"There's no doubt it will be challenging turnaround for us", he said.
"It is something that I experienced as a player and has remained with me".
Loose forward Jerome Kaino continues his recovery from knee surgery and misses out on Wednesday, but the blindside flanker is expected to be named in Steve Hansen's All Blacks squad on Thursday for their three tests against the Lions.
Akira Ioane will start in the number six jersey with Bristol-bound Steven Luatua remaining at the back of the scrum.
Celtics look to avoid elimination in Boston on KPUG
Avery Bradley was the leading scorer for the Celtics but only shot 7-19 from the field but did record five defensive rebounds. Boston led by as many as 16 points in Game 4 and once again had their bench out score the Cavaliers' bench by a large margin.