HBO, the network on which the show airs, was also deeply embarrassed by the comments.
Nearly immediately after Maher made the comment, numerous people on social media called for him to be fired or punished.
The network said it would remove the content from future airings of the Friday episode of the "Real Time with Bill Maher" show. "Me just cringing last night wasn't good enough".
The word was offensive and I regret saying it and am very sorry.
As Philly.com writer Rob Tornoe noted in an article published Saturday, this isn't the first time Maher has said something extremely offensive.
One Twitter user brought up a really interesting point..
Maher used the slur in an exchange with Sen.
Sasse was promoting his book, "The Vanishing American Adult", on "Real Time With Bill Maher".
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As the two were talking about adults dressing up for Halloween - relevant in regards to Sasse's release - Maher seemed to have liked the fact that Nebraska adults don't dress up for the holiday the way adults do in California. The comedian responded by using a slur in a joke that he was a house slave.
"Racist Bill Maher must be fired and @BenSasse must be held accountable for his endorsement of the n-word", he said on Twitter. He asked the senator if people do that in Nebraska.
"We'd love to have you work in the fields with us", Sasse said. "You can not allow folk to act like there's anything amusing in that context about using that word".
Sasse, who appeared visibly shocked by the comment, didn't say anything in response to Maher, prompting backlash against him as well. "Comedians get latitude to cross hard lines", he tweeted Saturday.
"Bill Maher must be fired immediately for his racism and belittling the struggle of millions of black Americans", wrote blogger Jack Posobiec. The history of the n-word is an attack on universal human dignity.
- Reverend Al Sharpton (@TheRevAl) June 3, 2017address this Bill Maher issue and our move on HBO at this morning's NAN Saturday Action Rally. "Lobbing cruise missiles from 2,000 miles away".